Assay Detail
Binding
CHEMBL667317
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Compound was evaluated for binding affinity against Dihydrofolate reductase of L1210 cells
5
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | L1210 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological activity of resolved C-10 diastereomers of 10-methyl- and 10-ethyl-10-deazaminopterin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 10.91 | 10.91 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2051990 | — | — | 1 | 10.91 |
| CHEMBL2051987 | — | — | 2 | - |
| CHEMBL3349020 | — | — | 1 | - |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2051990 | — | Ki | = | 0.0124 | nM | 10.91 |
| CHEMBL2051987 | — | Ki | = | 0.00424 | nM | - |
| CHEMBL3349020 | — | Ki | = | 0.00393 | nM | - |
| CHEMBL2051987 | — | Ki | = | 0.00317 | nM | - |
| CHEMBL34259 | METHOTREXATE | Ki | = | 0.00442 | nM | - |