Assay Detail
Binding
CHEMBL667325
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of the dihydrofolate reductase enzyme(DHFR) derived from L1210 murine leukemia cells.
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | L1210 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and antifolate properties of 5,10-ethano-5,10-dideazaaminopterin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 10.83 | 10.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL113799 | — | — | 1 | 10.89 |
| CHEMBL109229 | — | — | 1 | 10.77 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | - |
| CHEMBL110251 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL113799 | — | Ki | = | 0.013 | nM | 10.89 |
| CHEMBL109229 | — | Ki | = | 0.017 | nM | 10.77 |
| CHEMBL34259 | METHOTREXATE | Ki | = | 0.006 | nM | - |
| CHEMBL110251 | — | Ki | = | 0.007 | nM | - |