Assay Detail
Binding
CHEMBL667326
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Inhibitory activity of Dihydrofolate reductase derived from L1210 cell line.
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | L1210 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and antifolate properties of 10-alkyl-5,10-dideaza analogues of methotrexate and tetrahydrofolic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 10.89 | 10.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL113799 | — | — | 1 | 10.89 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | - |
| CHEMBL162414 | — | — | 1 | - |
| CHEMBL279508 | — | — | 1 | - |
| CHEMBL162701 | — | — | 1 | - |
| CHEMBL110251 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL113799 | — | Ki | = | 0.013 | nM | 10.89 |
| CHEMBL34259 | METHOTREXATE | Ki | = | 0.006 | nM | - |
| CHEMBL162414 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL279508 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL162701 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL110251 | — | Ki | = | 0.007 | nM | - |