Assay Detail
Binding
CHEMBL667327
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Inhibitory activity of Dihydrofolate reductase in L1210 cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | L1210 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Studies on analogues of classical antifolates bearing the naphthoyl group in place of benzoyl in the side chain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 10.88 | 10.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL134110 | — | — | 1 | 10.88 |
| CHEMBL132142 | — | — | 1 | - |
| CHEMBL335716 | — | — | 1 | - |
| CHEMBL132431 | — | — | 1 | - |
| CHEMBL136010 | — | — | 1 | - |
| CHEMBL341401 | — | — | 1 | - |
| CHEMBL134817 | — | — | 1 | - |
| CHEMBL337051 | — | — | 1 | - |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL134110 | — | Ki | = | 0.0131 | nM | 10.88 |
| CHEMBL132142 | — | Ki | = | 0.00365 | nM | - |
| CHEMBL335716 | — | Ki | = | 0.00455 | nM | - |
| CHEMBL132431 | — | Ki | = | 0.00522 | nM | - |
| CHEMBL136010 | — | Ki | = | 0.00465 | nM | - |
| CHEMBL341401 | — | Ki | = | 0.00508 | nM | - |
| CHEMBL134817 | — | Ki | = | 0.0052 | nM | - |
| CHEMBL337051 | — | Ki | = | 0.00484 | nM | - |
| CHEMBL34259 | METHOTREXATE | Ki | = | 0.00482 | nM | - |