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Assay Detail

CHEMBL667328

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory activity towards Dihydrofolate reductase derived from human manca leukemia cells
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Dihydrofolate reductase (CHEMBL4564)
Type SINGLE PROTEIN
Organism Mus musculus

Publication

Synthesis and antifolate properties of 9-alkyl-10-deazaminopterins.
DeGraw JI, Christie PH, Kisliuk RL, Gaumont Y, Sirotnak FM.
J Med Chem (1990) 33 : 212 -215
PubMed 2296020 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 5.09 5.09

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL302068 1 5.09

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL302068 Ki = 8200.0 nM 5.09