Assay Detail
Binding
CHEMBL667604
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Inhibitory activity against dihydrofolate reductase (DHFR) enzyme from Neisseria gonorrhoeae
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Neisseria gonorrhoeae |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
2,4-Diamino-5-benzylpyrimidines as antibacterial agents. 8. The 3,4,5-triethyl isostere of trimethoprim. A study of specificity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.31 | 6.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL57582 | — | — | 1 | 6.64 |
| CHEMBL22 | TRIMETHOPRIM | 4.0 | 1 | 6.35 |
| CHEMBL19633 | DIAVERIDINE | 2.0 | 1 | 6.28 |
| CHEMBL293013 | — | — | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL57582 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL22 | TRIMETHOPRIM | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL19633 | DIAVERIDINE | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL293013 | — | IC50 | = | 1110.0 | nM | 5.96 |