Assay Detail
Binding
CHEMBL667608
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Compound was tested for its inhibition against dihydrofolate reductase enzyme of Plasmodium berghei
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium berghei |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Bifunctional dihydrofolate reductase-thymidylate synthase (CHEMBL3963) ↗| Type | SINGLE PROTEIN |
| Organism | Plasmodium berghei str. ANKA |
Publication
2,4-Diamino-5-benzylpyrimidines as antibacterial agents. 4. 6-Substituted trimethoprim derivatives from phenolic Mannich intermediates. Application to the synthesis of trimethoprim and 3,5-dialkylbenzyl analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.38 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL22 | TRIMETHOPRIM | 4.0 | 1 | 6.92 |
| CHEMBL325533 | — | — | 1 | 6.47 |
| CHEMBL339058 | — | — | 1 | 6.32 |
| CHEMBL149353 | — | — | 1 | 5.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL22 | TRIMETHOPRIM | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL325533 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL339058 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL149353 | — | IC50 | = | 1500.0 | nM | 5.82 |