Assay Detail
Binding
CHEMBL667610
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against dihydrofolate reductase (DHFR) enzyme from Plasmodium berghei
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium berghei |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Bifunctional dihydrofolate reductase-thymidylate synthase (CHEMBL3963) ↗| Type | SINGLE PROTEIN |
| Organism | Plasmodium berghei str. ANKA |
Publication
2,4-Diamino-5-benzylpyrimidines as antibacterial agents. 8. The 3,4,5-triethyl isostere of trimethoprim. A study of specificity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.91 | 7.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL57582 | — | — | 1 | 7.14 |
| CHEMBL22 | TRIMETHOPRIM | 4.0 | 1 | 6.92 |
| CHEMBL19633 | DIAVERIDINE | 2.0 | 1 | 6.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL57582 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL22 | TRIMETHOPRIM | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL19633 | DIAVERIDINE | IC50 | = | 210.0 | nM | 6.68 |