Assay Detail
Binding
CHEMBL667766
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Inhibitory activity against dihydrofolate reductase (DHFR) of Plasmodium berghei
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium berghei |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Bifunctional dihydrofolate reductase-thymidylate synthase (CHEMBL3963) ↗| Type | SINGLE PROTEIN |
| Organism | Plasmodium berghei str. ANKA |
Publication
2,4-Diamino-5-benzylpyrimidines as antibacterial agents. 7. Analysis of the effect of 3,5-dialkyl substituent size and shape on binding to four different dihydrofolate reductase enzymes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 7.50 | 8.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL440334 | — | — | 1 | 8.24 |
| CHEMBL23746 | — | — | 1 | 8.24 |
| CHEMBL116183 | — | — | 1 | 8.12 |
| CHEMBL118877 | — | — | 1 | 8.00 |
| CHEMBL279455 | — | — | 1 | 8.00 |
| CHEMBL23250 | — | — | 1 | 7.92 |
| CHEMBL24374 | — | — | 1 | 7.89 |
| CHEMBL25888 | — | — | 1 | 7.82 |
| CHEMBL26337 | — | — | 1 | 7.70 |
| CHEMBL280374 | — | — | 1 | 7.64 |
| CHEMBL25817 | — | — | 1 | 7.55 |
| CHEMBL120366 | — | — | 1 | 7.51 |
| CHEMBL116993 | — | — | 1 | 7.47 |
| CHEMBL332481 | — | — | 1 | 7.46 |
| CHEMBL118367 | — | — | 1 | 7.38 |
| CHEMBL118480 | — | — | 1 | 7.28 |
| CHEMBL24155 | — | — | 1 | 7.11 |
| CHEMBL440946 | — | — | 1 | 6.96 |
| CHEMBL23447 | — | — | 1 | 6.92 |
| CHEMBL287553 | — | — | 1 | 6.92 |
| CHEMBL22 | TRIMETHOPRIM | 4.0 | 1 | 6.92 |
| CHEMBL277176 | — | — | 1 | 6.85 |
| CHEMBL1181 | 4-HYDROXYTRIMETHOPRIM | — | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL440334 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL23746 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL116183 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL118877 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL279455 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL23250 | — | IC50 | = | 12.1 | nM | 7.92 |
| CHEMBL24374 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL25888 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL26337 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL280374 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL25817 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL120366 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL116993 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL332481 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL118367 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL118480 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL24155 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL440946 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL23447 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL287553 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL22 | TRIMETHOPRIM | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL277176 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL1181 | 4-HYDROXYTRIMETHOPRIM | IC50 | = | 300.0 | nM | 6.52 |