Assay Detail
Binding
CHEMBL668082
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Inhibitory concentration against CCRF-CEM leukemic cell DHFR(Dihydro folate reductase).
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CCRF-CEM |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Effect of bridge region variation on antifolate and antitumor activity of classical 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.76 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 9.15 |
| CHEMBL323565 | — | — | 1 | 6.60 |
| CHEMBL106699 | — | — | 1 | 4.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL323565 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL106699 | — | IC50 | = | 30500.0 | nM | 4.52 |