Assay Detail
Binding
CHEMBL668084
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Inhibitory concentration for DHFR in recombinant human
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Classical and nonclassical furo[2,3-d]pyrimidines as novel antifolates: synthesis and biological activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.14 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 8.40 |
| CHEMBL278515 | — | — | 1 | 6.66 |
| CHEMBL17383 | — | — | 1 | 6.35 |
| CHEMBL274278 | — | — | 1 | - |
| CHEMBL16950 | — | — | 1 | - |
| CHEMBL17044 | — | — | 1 | - |
| CHEMBL17235 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL278515 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL17383 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL274278 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL16950 | — | IC50 | > | 26000.0 | nM | - |
| CHEMBL17044 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL17235 | — | IC50 | > | 25000.0 | nM | - |