Assay Detail
Binding
CHEMBL668085
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Tested for inhibitory activity against dihydrofolate reductase in human
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
2,4-Diaminothieno[2,3-d]pyrimidine analogues of trimetrexate and piritrexim as potential inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.04 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL119 | TRIMETREXATE | 4.0 | 1 | 8.85 |
| CHEMBL104787 | — | — | 1 | 6.14 |
| CHEMBL323960 | — | — | 1 | 6.12 |
| CHEMBL326200 | — | — | 1 | - |
| CHEMBL322585 | — | — | 1 | - |
| CHEMBL322315 | — | — | 1 | - |
| CHEMBL322861 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL119 | TRIMETREXATE | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL104787 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL323960 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL326200 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL322585 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL322315 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL322861 | — | IC50 | > | 10000.0 | nM | - |