Assay Detail
Binding
CHEMBL668092
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against Dihydrofolate reductase from Toxoplasma gondii (Toxoplasma gondii)
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Toxoplasma gondii |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Bifunctional dihydrofolate reductase-thymidylate synthase (CHEMBL2425) ↗| Type | SINGLE PROTEIN |
| Organism | Toxoplasma gondii |
Publication
Design, synthesis, and biological evaluation of 2,4-diamino-5-methyl-6-substituted-pyrrolo[2,3-d]pyrimidines as dihydrofolate reductase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.80 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL119 | TRIMETREXATE | 4.0 | 1 | 8.00 |
| CHEMBL122998 | — | — | 1 | 6.80 |
| CHEMBL331986 | — | — | 1 | 6.77 |
| CHEMBL331314 | — | — | 1 | 5.99 |
| CHEMBL123892 | — | — | 1 | 5.57 |
| CHEMBL331292 | — | — | 1 | 5.55 |
| CHEMBL123984 | — | — | 1 | 5.32 |
| CHEMBL334198 | — | — | 1 | 5.16 |
| CHEMBL420172 | — | — | 1 | 5.05 |
| CHEMBL283311 | — | — | 1 | 4.94 |
| CHEMBL331456 | — | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL119 | TRIMETREXATE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL122998 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL331986 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL331314 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL123892 | — | IC50 | = | 2690.0 | nM | 5.57 |
| CHEMBL331292 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL123984 | — | IC50 | = | 4760.0 | nM | 5.32 |
| CHEMBL334198 | — | IC50 | = | 6940.0 | nM | 5.16 |
| CHEMBL420172 | — | IC50 | = | 8930.0 | nM | 5.05 |
| CHEMBL283311 | — | IC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL331456 | — | IC50 | = | 20000.0 | nM | 4.70 |