Assay Detail
Binding
CHEMBL668093
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Compound was evaluated for Dihydrofolate Reductase (DHFR) inhibition
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological activity of the 2-desamino and 2-desamino-2-methyl analogues of aminopterin and methotrexate.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.29 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 7.62 |
| CHEMBL376180 | AMINOPTERIN | 2.0 | 1 | 7.60 |
| CHEMBL74422 | — | — | 1 | 5.22 |
| CHEMBL430797 | — | — | 1 | 4.72 |
| CHEMBL307137 | — | — | 1 | - |
| CHEMBL419087 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL376180 | AMINOPTERIN | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL74422 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL430797 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL307137 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL419087 | — | IC50 | > | 20000.0 | nM | - |