Assay Detail
Binding
CHEMBL668275
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity towards dihydrofolate reductase derived from human manca leukemia cells
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and antifolate properties of 9-alkyl-10-deazaminopterins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.46 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 7.52 |
| CHEMBL431359 | — | — | 1 | 7.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL431359 | — | IC50 | = | 40.0 | nM | 7.40 |