Assay Detail
Binding
CHEMBL668874
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In vitro binding affinity to Dopamine receptor D1/Dopamine receptor D2 in rat striatal membranes using [3H]N-propylnorapomorphine
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Striatum |
| Subcellular | Membrane |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Dopamine receptors; D1 & D2 (CHEMBL2096910) ↗| Type | SELECTIVITY GROUP |
| Organism | Rattus norvegicus |
Publication
Synthesis and dopaminergic activity of the enantiomers of 6-methyl-4,5a,6,7,8-hexahydrothiazolo[4,5-f]quinolin-2-amine (PD 128483).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.08 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53 | APOMORPHINE | 4.0 | 1 | 8.77 |
| CHEMBL150523 | — | — | 1 | 6.90 |
| CHEMBL150551 | — | — | 1 | 6.86 |
| CHEMBL150550 | — | — | 1 | 6.53 |
| CHEMBL348012 | — | — | 1 | 6.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53 | APOMORPHINE | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL150523 | — | IC50 | = | 127.0 | nM | 6.90 |
| CHEMBL150551 | — | IC50 | = | 138.0 | nM | 6.86 |
| CHEMBL150550 | — | IC50 | = | 295.0 | nM | 6.53 |
| CHEMBL348012 | — | IC50 | = | 464.0 | nM | 6.33 |