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Assay Detail

CHEMBL669149

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
In vitro ability to inhibit [3H]raclopride binding to cloned human D2A receptors expressed in mouse fibroblast (LtK-) cells
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

D(2) dopamine receptor (CHEMBL217)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Novel derivatives of 3-(dipropylamino)chroman. Interactions with 5-HT1A and D2A receptors.
Caldirola P, Chowdhury R, Unelius L, Mohell N, Hacksell U, Johansson AM.
Bioorg Med Chem Lett (1999) 9 : 1583 -1586
PubMed 10386940 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 15 6.40 7.32

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL38580 1 7.32
CHEMBL38428 1 6.89
CHEMBL39847 1 6.40
CHEMBL41134 1 6.23
CHEMBL43073 1 6.12
CHEMBL41200 1 5.96
CHEMBL38656 1 5.87
CHEMBL41759 1 -
CHEMBL41120 1 -
CHEMBL38855 1 -
CHEMBL43359 1 -
CHEMBL41491 1 -
CHEMBL291251 1 -
CHEMBL27995 1 -
CHEMBL42857 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL38580 Ki = 47.5 nM 7.32
CHEMBL38428 Ki = 128.0 nM 6.89
CHEMBL39847 Ki = 398.0 nM 6.40
CHEMBL41134 Ki = 590.0 nM 6.23
CHEMBL43073 Ki = 763.0 nM 6.12
CHEMBL41200 Ki = 1090.0 nM 5.96
CHEMBL38656 Ki = 1360.0 nM 5.87
CHEMBL41759 Ki > 1000.0 nM -
CHEMBL41120 Ki > 1000.0 nM -
CHEMBL38855 Ki > 1000.0 nM -
CHEMBL43359 Ki > 1000.0 nM -
CHEMBL41491 Ki > 1000.0 nM -
CHEMBL291251 Ki > 1000.0 nM -
CHEMBL27995 Ki > 3000.0 nM -
CHEMBL42857 Ki > 1000.0 nM -