Assay Detail
Binding
CHEMBL669163
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Binding affinity towards human cloned dopamine (hD3) receptor expressed in CHO cells using [3H]spiperone as radioligand
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
New generation dopaminergic agents. 2. Discovery of 3-OH-phenoxyethylamine and 3-OH-N1-phenylpiperazine dopaminergic templates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 7.82 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL300571 | — | — | 1 | 8.96 |
| CHEMBL64553 | — | — | 1 | 8.62 |
| CHEMBL64508 | — | — | 1 | 7.96 |
| CHEMBL99913 | — | — | 1 | 7.96 |
| CHEMBL102490 | — | — | 1 | 7.56 |
| CHEMBL88365 | — | — | 1 | 7.54 |
| CHEMBL99849 | — | — | 1 | 7.37 |
| CHEMBL101285 | — | — | 1 | 6.55 |
| CHEMBL101910 | — | — | 1 | - |
| CHEMBL100461 | — | — | 1 | - |
| CHEMBL103900 | — | — | 1 | - |
| CHEMBL100952 | — | — | 1 | - |
| CHEMBL103951 | — | — | 1 | - |
| CHEMBL323118 | — | — | 1 | - |
| CHEMBL101032 | — | — | 1 | - |
| CHEMBL319816 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL300571 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL64553 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL64508 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL99913 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL102490 | — | Ki | = | 27.8 | nM | 7.56 |
| CHEMBL88365 | — | Ki | = | 28.9 | nM | 7.54 |
| CHEMBL99849 | — | Ki | = | 42.5 | nM | 7.37 |
| CHEMBL101285 | — | Ki | = | 281.5 | nM | 6.55 |
| CHEMBL101910 | — | Ki | > | 400.0 | nM | - |
| CHEMBL100461 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL103900 | — | Ki | > | 400.0 | nM | - |
| CHEMBL100952 | — | Ki | > | 400.0 | nM | - |
| CHEMBL103951 | — | Ki | > | 400.0 | nM | - |
| CHEMBL323118 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL101032 | — | Ki | > | 400.0 | nM | - |
| CHEMBL319816 | — | Ki | > | 1000.0 | nM | - |