Assay Detail
Binding
CHEMBL669212
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Inhibitory activity against human liver Dihydrodipicolinate reductase (DHPR)
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and dihydropteridine reductase inhibitory effects of potential metabolites of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 5.31 | 6.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL324880 | — | — | 1 | 6.55 |
| CHEMBL110377 | — | — | 1 | 6.42 |
| CHEMBL109090 | — | — | 1 | 6.20 |
| CHEMBL108967 | — | — | 1 | 5.52 |
| CHEMBL323998 | — | — | 1 | 5.47 |
| CHEMBL105897 | — | — | 1 | 5.44 |
| CHEMBL110621 | — | — | 1 | 5.30 |
| CHEMBL108679 | — | — | 1 | 5.28 |
| CHEMBL108787 | — | — | 1 | 5.23 |
| CHEMBL108496 | — | — | 1 | 5.14 |
| CHEMBL322323 | — | — | 1 | 5.03 |
| CHEMBL109076 | — | — | 1 | 4.72 |
| CHEMBL108680 | — | — | 1 | 4.57 |
| CHEMBL321432 | — | — | 1 | 4.38 |
| CHEMBL110602 | — | — | 1 | 4.36 |
| CHEMBL109074 | — | — | 1 | - |
| CHEMBL105891 | — | — | 1 | - |
| CHEMBL101664 | — | — | 1 | - |
| CHEMBL98417 | — | — | 1 | - |
| CHEMBL6224 | — | — | 1 | - |
| CHEMBL108926 | — | — | 1 | - |
| CHEMBL108466 | — | — | 1 | - |
| CHEMBL24172 | — | — | 1 | - |
| CHEMBL106131 | — | — | 1 | - |
| CHEMBL110142 | — | — | 1 | - |
| CHEMBL440702 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL324880 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL110377 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL109090 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL108967 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL323998 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL105897 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL110621 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL108679 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL108787 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL108496 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL322323 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL109076 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL108680 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL321432 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL110602 | — | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL109074 | — | IC50 | = | 2400000.0 | nM | - |
| CHEMBL105891 | — | IC50 | = | 5600000.0 | nM | - |
| CHEMBL101664 | — | IC50 | = | 3400000.0 | nM | - |
| CHEMBL98417 | — | IC50 | = | 23000000.0 | nM | - |
| CHEMBL6224 | — | IC50 | = | 12000000.0 | nM | - |
| CHEMBL108926 | — | IC50 | = | 10000000.0 | nM | - |
| CHEMBL108466 | — | IC50 | = | 1100000.0 | nM | - |
| CHEMBL24172 | — | IC50 | = | 3000000.0 | nM | - |
| CHEMBL106131 | — | IC50 | = | 9400000.0 | nM | - |
| CHEMBL110142 | — | IC50 | = | 5300000.0 | nM | - |
| CHEMBL440702 | — | IC50 | = | 2700000.0 | nM | - |