Assay Detail
Binding
CHEMBL669252
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested in vitro for inhibitory concentration against CCRF-CEM human Leukemic lymphoblast by using DHFR as primary target
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CCRF-CEM |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological activity of N omega-hemiphthaloyl-alpha,omega- diaminoalkanoic acid analogues of aminopterin and 3',5-dichloroaminopterin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.69 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18155 | — | — | 1 | 8.96 |
| CHEMBL296373 | EDATREXATE | 2.0 | 1 | 8.59 |
| CHEMBL376180 | AMINOPTERIN | 2.0 | 1 | 8.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18155 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL296373 | EDATREXATE | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL376180 | AMINOPTERIN | IC50 | = | 3.0 | nM | 8.52 |