Assay Detail
Binding
CHEMBL669254
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Tested for 50% inhibition of WI-L2 Dihydrofolate reductase
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Potent inhibition of thymidylate synthase by two series of nonclassical quinazolines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.49 | 5.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL422395 | — | — | 1 | 5.14 |
| CHEMBL304407 | — | — | 1 | 4.99 |
| CHEMBL302669 | — | — | 1 | 4.69 |
| CHEMBL62769 | — | — | 1 | 4.65 |
| CHEMBL62599 | — | — | 1 | 4.43 |
| CHEMBL433059 | — | — | 1 | 4.18 |
| CHEMBL62675 | — | — | 1 | 4.18 |
| CHEMBL417562 | — | — | 1 | 4.14 |
| CHEMBL64215 | — | — | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL422395 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL304407 | — | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL302669 | — | IC50 | = | 20300.0 | nM | 4.69 |
| CHEMBL62769 | — | IC50 | = | 22600.0 | nM | 4.65 |
| CHEMBL62599 | — | IC50 | = | 37300.0 | nM | 4.43 |
| CHEMBL433059 | — | IC50 | = | 66600.0 | nM | 4.18 |
| CHEMBL62675 | — | IC50 | = | 66600.0 | nM | 4.18 |
| CHEMBL417562 | — | IC50 | = | 72600.0 | nM | 4.14 |
| CHEMBL64215 | — | IC50 | = | 100000.0 | nM | 4.00 |