Assay Detail
Binding
CHEMBL669263
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Apparent dissociation constant at pH 6.6 for human dihydrofolate reductase in the presence of cofactor NADPH
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structure-activity relationships and pH dependence of binding of 8-alkyl-N5-deazapterins to dihydrofolate reductase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 16 | 5.62 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL135937 | — | — | 1 | 7.10 |
| CHEMBL436184 | — | — | 1 | 6.30 |
| CHEMBL336628 | — | — | 1 | 6.22 |
| CHEMBL135936 | — | — | 1 | 6.16 |
| CHEMBL134613 | — | — | 1 | 6.16 |
| CHEMBL340269 | — | — | 1 | 5.92 |
| CHEMBL133360 | — | — | 1 | 5.72 |
| CHEMBL135581 | — | — | 1 | 5.70 |
| CHEMBL341200 | — | — | 1 | 5.54 |
| CHEMBL135811 | — | — | 1 | 5.40 |
| CHEMBL135905 | — | — | 1 | 5.34 |
| CHEMBL424647 | — | — | 1 | 5.29 |
| CHEMBL134466 | — | — | 1 | 4.89 |
| CHEMBL134383 | — | — | 1 | 4.80 |
| CHEMBL136042 | — | — | 1 | 4.75 |
| CHEMBL135622 | — | — | 1 | 4.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL135937 | — | Kd | = | 80.0 | nM | 7.10 |
| CHEMBL436184 | — | Kd | = | 500.0 | nM | 6.30 |
| CHEMBL336628 | — | Kd | = | 600.0 | nM | 6.22 |
| CHEMBL135936 | — | Kd | = | 700.0 | nM | 6.16 |
| CHEMBL134613 | — | Kd | = | 700.0 | nM | 6.16 |
| CHEMBL340269 | — | Kd | = | 1200.0 | nM | 5.92 |
| CHEMBL133360 | — | Kd | = | 1900.0 | nM | 5.72 |
| CHEMBL135581 | — | Kd | = | 2000.0 | nM | 5.70 |
| CHEMBL341200 | — | Kd | = | 2900.0 | nM | 5.54 |
| CHEMBL135811 | — | Kd | = | 4000.0 | nM | 5.40 |
| CHEMBL135905 | — | Kd | = | 4600.0 | nM | 5.34 |
| CHEMBL424647 | — | Kd | = | 5100.0 | nM | 5.29 |
| CHEMBL134466 | — | Kd | = | 13000.0 | nM | 4.89 |
| CHEMBL134383 | — | Kd | = | 16000.0 | nM | 4.80 |
| CHEMBL136042 | — | Kd | = | 18000.0 | nM | 4.75 |
| CHEMBL135622 | — | Kd | = | 21000.0 | nM | 4.68 |