Assay Detail
Binding
CHEMBL669266
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested for the apparent dissociation constant for binding of compound to binary NADPH complex with human dihydrofolate reductase using equations 11 and 12
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Structure-activity relationships and pH dependence of binding of 8-alkyl-N5-deazapterins to dihydrofolate reductase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 5.58 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL135581 | — | — | 1 | 5.92 |
| CHEMBL135937 | — | — | 1 | 5.58 |
| CHEMBL135811 | — | — | 1 | 5.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL135581 | — | Kd | = | 1200.0 | nM | 5.92 |
| CHEMBL135937 | — | Kd | = | 2600.0 | nM | 5.58 |
| CHEMBL135811 | — | Kd | = | 5800.0 | nM | 5.24 |