Assay Detail
Binding
CHEMBL669279
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In vitro inhibition of human dihydrofolate reductase
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Selective inhibitors of Candida albicans dihydrofolate reductase: activity and selectivity of 5-(arylthio)-2,4-diaminoquinazolines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 5.89 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7492 | PIRITREXIM | 2.0 | 1 | 8.70 |
| CHEMBL121669 | — | — | 1 | 7.52 |
| CHEMBL334307 | — | — | 1 | 7.04 |
| CHEMBL123353 | — | — | 1 | 6.75 |
| CHEMBL121057 | — | — | 1 | 6.70 |
| CHEMBL338742 | — | — | 1 | 6.57 |
| CHEMBL333769 | — | — | 1 | 6.50 |
| CHEMBL121303 | — | — | 1 | 6.40 |
| CHEMBL121595 | — | — | 1 | 6.26 |
| CHEMBL100239 | — | — | 1 | 6.21 |
| CHEMBL420721 | — | — | 1 | 6.09 |
| CHEMBL83547 | — | — | 1 | 6.03 |
| CHEMBL118490 | — | — | 1 | 5.89 |
| CHEMBL121644 | — | — | 1 | 5.70 |
| CHEMBL329985 | — | — | 1 | 5.70 |
| CHEMBL310759 | — | — | 1 | 5.68 |
| CHEMBL124304 | — | — | 1 | 5.62 |
| CHEMBL413110 | — | — | 1 | 5.58 |
| CHEMBL36 | PYRIMETHAMINE | 4.0 | 1 | 5.58 |
| CHEMBL118316 | — | — | 1 | 5.51 |
| CHEMBL330868 | — | — | 1 | 5.46 |
| CHEMBL123061 | — | — | 1 | 5.41 |
| CHEMBL122647 | — | — | 1 | 5.39 |
| CHEMBL333976 | — | — | 1 | 5.37 |
| CHEMBL120588 | — | — | 1 | 5.37 |
| CHEMBL120924 | — | — | 1 | 5.36 |
| CHEMBL122628 | — | — | 1 | 5.04 |
| CHEMBL121680 | — | — | 1 | 4.62 |
| CHEMBL120783 | — | — | 1 | 4.48 |
| CHEMBL328827 | — | — | 1 | 4.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7492 | PIRITREXIM | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL121669 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL334307 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL123353 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL121057 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL338742 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL333769 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL121303 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL121595 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL100239 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL420721 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL83547 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL118490 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL121644 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL329985 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL310759 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL124304 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL413110 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL36 | PYRIMETHAMINE | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL118316 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL330868 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL123061 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL122647 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL333976 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL120588 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL120924 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL122628 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL121680 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL120783 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL328827 | — | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL22 | TRIMETHOPRIM | IC50 | = | 490000.0 | nM | - |
| CHEMBL119 | TRIMETREXATE | IC50 | < | 1.0 | nM | - |
| CHEMBL334017 | — | IC50 | > | 10000.0 | nM | - |