Assay Detail
Binding
CHEMBL669642
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Evaluated for the inhibition of dihydrofolate reductase from L1210 mouse leukemia cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | L1210 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Chemistry and antitumor evaluation of selected classical 2,4-diaminoquinazoline analogues of folic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.26 | 7.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 7.35 |
| CHEMBL305253 | — | — | 1 | 7.29 |
| CHEMBL423123 | — | — | 1 | 7.22 |
| CHEMBL69713 | — | — | 1 | 7.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL305253 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL423123 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL69713 | — | IC50 | = | 70.0 | nM | 7.16 |