Assay Detail
Binding
CHEMBL669646
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of dihydrofolate reductase (DHFR) from murine leukemia cells
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Methotrexate analogues. 33. N delta-acyl-N alpha-(4-amino-4-deoxypteroyl)-L-ornithine derivatives: synthesis and in vitro antitumor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.45 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL283702 | — | — | 1 | 7.82 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 7.60 |
| CHEMBL27109 | — | — | 1 | 7.57 |
| CHEMBL441418 | — | — | 1 | 7.55 |
| CHEMBL423297 | — | — | 1 | 7.55 |
| CHEMBL416193 | — | — | 1 | 7.50 |
| CHEMBL27514 | — | — | 1 | 7.47 |
| CHEMBL376180 | AMINOPTERIN | 2.0 | 1 | 7.46 |
| CHEMBL27821 | — | — | 1 | 7.35 |
| CHEMBL26534 | — | — | 1 | 7.28 |
| CHEMBL18155 | — | — | 1 | 7.28 |
| CHEMBL405237 | — | — | 1 | 7.25 |
| CHEMBL280864 | — | — | 1 | 7.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL283702 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL27109 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL441418 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL423297 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL416193 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL27514 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL376180 | AMINOPTERIN | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL27821 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL26534 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL18155 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL405237 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL280864 | — | IC50 | = | 72.0 | nM | 7.14 |