Assay Detail
Binding
CHEMBL669720
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In vitro 50% inhibition of topoisomerase II mediated k-DNA decatenation
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
9-substituted acridine derivatives with long half-life and potent antitumor activity: synthesis and structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 5.71 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL108283 | — | — | 1 | 7.70 |
| CHEMBL326664 | — | — | 1 | 7.35 |
| CHEMBL322325 | — | — | 1 | 7.27 |
| CHEMBL325543 | — | — | 1 | 7.20 |
| CHEMBL108404 | — | — | 1 | 6.94 |
| CHEMBL325588 | — | — | 1 | 6.65 |
| CHEMBL321473 | — | — | 1 | 6.00 |
| CHEMBL43 | AMSACRINE | 4.0 | 1 | 6.00 |
| CHEMBL111592 | — | — | 1 | 5.53 |
| CHEMBL111261 | — | — | 1 | 4.70 |
| CHEMBL326274 | — | — | 1 | 4.70 |
| CHEMBL322491 | — | — | 1 | 4.70 |
| CHEMBL320354 | — | — | 1 | 4.70 |
| CHEMBL109942 | — | — | 1 | 4.70 |
| CHEMBL111735 | — | — | 1 | 4.30 |
| CHEMBL320495 | — | — | 1 | 4.30 |
| CHEMBL109880 | — | — | 1 | 4.30 |
| CHEMBL444329 | — | — | 1 | - |
| CHEMBL111502 | — | — | 1 | - |
| CHEMBL109534 | — | — | 1 | - |
| CHEMBL109922 | — | — | 1 | - |
| CHEMBL108493 | — | — | 1 | - |
| CHEMBL109928 | — | — | 1 | - |
| CHEMBL109743 | — | — | 1 | - |
| CHEMBL109468 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL108283 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL326664 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL322325 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL325543 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL108404 | — | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL325588 | — | IC50 | = | 226.0 | nM | 6.65 |
| CHEMBL321473 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL43 | AMSACRINE | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL111592 | — | IC50 | = | 2970.0 | nM | 5.53 |
| CHEMBL111261 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL326274 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL322491 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL320354 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL109942 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL111735 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL320495 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL109880 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL444329 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL111502 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL109534 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL109922 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL108493 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL109928 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL109743 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL109468 | — | IC50 | > | 100000.0 | nM | - |