Assay Detail
Binding
CHEMBL669946
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The compound was evaluated for the binding affinity towards dopamine receptor D2 at low affinity state.
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
(+/-)-3-Allyl-6-bromo-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3- benzazepin, a new high-affinity D1 dopamine receptor ligand: synthesis and structure-activity relationship.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 5.19 | 5.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL543398 | — | — | 1 | 5.57 |
| CHEMBL554009 | — | — | 1 | 5.40 |
| CHEMBL553503 | — | — | 1 | 5.10 |
| CHEMBL544114 | — | — | 1 | 4.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL543398 | — | Ki | = | 2700.0 | nM | 5.57 |
| CHEMBL554009 | — | Ki | = | 4000.0 | nM | 5.40 |
| CHEMBL553503 | — | Ki | = | 8000.0 | nM | 5.10 |
| CHEMBL544114 | — | Ki | = | 21000.0 | nM | 4.68 |