Assay Detail
Functional
CHEMBL669947
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Dopamine receptor D2 agonist activity was determined for inhibition of the constrictor response to electrical stimulation in an isolated perfused rabbit ear artery preparation
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Dopamine agonists related to 3-allyl-6-chloro-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-1H-3-benzaz epi ne-7, 8-diol. 6-Position modifications.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 6.74 | 6.86 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129634 | — | — | 1 | 6.86 |
| CHEMBL131313 | — | — | 1 | 6.76 |
| CHEMBL540575 | — | — | 1 | 6.60 |
| CHEMBL538785 | — | — | 1 | - |
| CHEMBL552611 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129634 | — | EC50 | = | 137.0 | nM | 6.86 |
| CHEMBL131313 | — | EC50 | = | 174.0 | nM | 6.76 |
| CHEMBL540575 | — | EC50 | = | 253.0 | nM | 6.60 |
| CHEMBL538785 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL552611 | — | EC50 | > | 10000.0 | nM | - |