Assay Detail
Binding
CHEMBL669982
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Inhibitory concentration against Dihydrofolate reductase from Mycobacterium avium (Mycobacterium avium)
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycobacterium avium |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Design, synthesis, and biological evaluation of 2,4-diamino-5-methyl-6-substituted-pyrrolo[2,3-d]pyrimidines as dihydrofolate reductase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.26 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL119 | TRIMETREXATE | 4.0 | 1 | 8.82 |
| CHEMBL331986 | — | — | 1 | 7.00 |
| CHEMBL331314 | — | — | 1 | 6.52 |
| CHEMBL331292 | — | — | 1 | 6.52 |
| CHEMBL123892 | — | — | 1 | 6.22 |
| CHEMBL122998 | — | — | 1 | 6.16 |
| CHEMBL123984 | — | — | 1 | 5.86 |
| CHEMBL420172 | — | — | 1 | 5.40 |
| CHEMBL334198 | — | — | 1 | 5.36 |
| CHEMBL331456 | — | — | 1 | 4.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL119 | TRIMETREXATE | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL331986 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL331314 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL331292 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL123892 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL122998 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL123984 | — | IC50 | = | 1370.0 | nM | 5.86 |
| CHEMBL420172 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL334198 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL331456 | — | IC50 | = | 19000.0 | nM | 4.72 |