Assay Detail
Binding
CHEMBL669983
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Inhibition of Dihydrofolate reductase from Pneumocystis carinii (Pneumocystis carinii)
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Pneumocystis carinii |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design, synthesis, and biological evaluation of 2,4-diamino-5-methyl-6-substituted-pyrrolo[2,3-d]pyrimidines as dihydrofolate reductase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.07 | 7.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL119 | TRIMETREXATE | 4.0 | 1 | 7.38 |
| CHEMBL283311 | — | — | 1 | 6.19 |
| CHEMBL331456 | — | — | 1 | 4.92 |
| CHEMBL331292 | — | — | 1 | 4.92 |
| CHEMBL331986 | — | — | 1 | 4.84 |
| CHEMBL420172 | — | — | 1 | 4.78 |
| CHEMBL331314 | — | — | 1 | 4.66 |
| CHEMBL122998 | — | — | 1 | 4.43 |
| CHEMBL334198 | — | — | 1 | 4.37 |
| CHEMBL123984 | — | — | 1 | 4.22 |
| CHEMBL123892 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL119 | TRIMETREXATE | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL283311 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL331456 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL331292 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL331986 | — | IC50 | = | 14600.0 | nM | 4.84 |
| CHEMBL420172 | — | IC50 | = | 16700.0 | nM | 4.78 |
| CHEMBL331314 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL122998 | — | IC50 | = | 37300.0 | nM | 4.43 |
| CHEMBL334198 | — | IC50 | = | 42900.0 | nM | 4.37 |
| CHEMBL123984 | — | IC50 | = | 60200.0 | nM | 4.22 |
| CHEMBL123892 | — | IC50 | = | 112000.0 | nM | - |