Assay Detail
Binding
CHEMBL669986
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Antimycobacterial activity against human dihydrofolate reductase (hDHFR)
76
Total Activities
76
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Pharmacophore mapping of a series of 2,4-diamino-5-deazapteridine inhibitors of Mycobacterium avium complex dihydrofolate reductase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 76 | 7.13 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL150317 | — | — | 1 | 8.70 |
| CHEMBL281648 | — | — | 1 | 8.57 |
| CHEMBL150470 | — | — | 1 | 8.55 |
| CHEMBL151674 | — | — | 1 | 8.49 |
| CHEMBL148577 | — | — | 1 | 8.44 |
| CHEMBL148814 | — | — | 1 | 8.43 |
| CHEMBL359144 | — | — | 1 | 8.42 |
| CHEMBL346666 | — | — | 1 | 8.40 |
| CHEMBL358884 | — | — | 1 | 8.39 |
| CHEMBL151958 | — | — | 1 | 8.37 |
| CHEMBL23867 | — | — | 1 | 8.37 |
| CHEMBL147131 | — | — | 1 | 8.34 |
| CHEMBL23532 | — | — | 1 | 8.33 |
| CHEMBL81820 | — | — | 1 | 8.30 |
| CHEMBL283518 | — | — | 1 | 8.29 |
| CHEMBL147124 | — | — | 1 | 8.28 |
| CHEMBL23963 | — | — | 1 | 8.26 |
| CHEMBL148877 | — | — | 1 | 8.23 |
| CHEMBL151451 | — | — | 1 | 8.21 |
| CHEMBL147256 | — | — | 1 | 8.21 |
| CHEMBL150382 | — | — | 1 | 8.21 |
| CHEMBL150082 | — | — | 1 | 8.17 |
| CHEMBL347974 | — | — | 1 | 8.17 |
| CHEMBL147469 | — | — | 1 | 8.15 |
| CHEMBL147257 | — | — | 1 | 8.10 |
| CHEMBL22623 | — | — | 1 | 8.06 |
| CHEMBL345258 | — | — | 1 | 8.00 |
| CHEMBL151367 | — | — | 1 | 8.00 |
| CHEMBL149101 | — | — | 1 | 7.92 |
| CHEMBL356620 | — | — | 1 | 7.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL150317 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL281648 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL150470 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL151674 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL148577 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL148814 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL359144 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL346666 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL358884 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL151958 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL23867 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL147131 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL23532 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL81820 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL283518 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL147124 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL23963 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL148877 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL151451 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL147256 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL150382 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL150082 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL347974 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL147469 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL147257 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL22623 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL151367 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL345258 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL149101 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL356620 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL151947 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL80066 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL358195 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL347061 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL345708 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL23416 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL146968 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL23076 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL149273 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL23383 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL147504 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL151109 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL81119 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL282948 | — | IC50 | = | 142.0 | nM | 6.85 |
| CHEMBL23713 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL348209 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL347088 | — | IC50 | = | 277.0 | nM | 6.56 |
| CHEMBL279705 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL358381 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL24007 | — | IC50 | = | 420.0 | nM | 6.38 |