Assay Detail
Binding
CHEMBL670100
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Inhibition of [3H]spiperone binding to human Dopamine receptor D4.4 expressed in CHO cell membranes
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
New generation dopaminergic agents. 7. Heterocyclic bioisosteres that exploit the 3-OH-phenoxyethylamine D2 template.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 7.65 | 8.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL87192 | — | — | 1 | 8.51 |
| CHEMBL327782 | — | — | 1 | 8.42 |
| CHEMBL314174 | — | — | 1 | 8.20 |
| CHEMBL86504 | — | — | 1 | 8.15 |
| CHEMBL59752 | — | — | 1 | 8.00 |
| CHEMBL89037 | — | — | 1 | 7.95 |
| CHEMBL329398 | — | — | 1 | 7.80 |
| CHEMBL89420 | — | — | 1 | 7.29 |
| CHEMBL87067 | — | — | 1 | 7.21 |
| CHEMBL64508 | — | — | 1 | 7.09 |
| CHEMBL64283 | — | — | 1 | 6.64 |
| CHEMBL87137 | — | — | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL87192 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL327782 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL314174 | — | Ki | = | 6.3 | nM | 8.20 |
| CHEMBL86504 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL59752 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL89037 | — | Ki | = | 11.2 | nM | 7.95 |
| CHEMBL329398 | — | Ki | = | 15.8 | nM | 7.80 |
| CHEMBL89420 | — | Ki | = | 51.6 | nM | 7.29 |
| CHEMBL87067 | — | Ki | = | 61.1 | nM | 7.21 |
| CHEMBL64508 | — | Ki | = | 80.6 | nM | 7.09 |
| CHEMBL64283 | — | Ki | = | 230.2 | nM | 6.64 |
| CHEMBL87137 | — | Ki | = | 315.5 | nM | 6.50 |