Assay Detail
Binding
CHEMBL670363
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Inhibitory activity against Dopamine receptor D2 from mice
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and evaluation of heterocyclic carboxamides as potential antipsychotic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.89 | 8.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL342742 | — | — | 1 | 8.33 |
| CHEMBL141319 | — | — | 1 | 8.12 |
| CHEMBL141485 | — | — | 1 | 7.96 |
| CHEMBL358268 | — | — | 1 | 7.85 |
| CHEMBL142456 | — | — | 1 | 7.85 |
| CHEMBL143447 | — | — | 1 | 7.80 |
| CHEMBL142211 | — | — | 1 | 7.62 |
| CHEMBL141494 | — | — | 1 | 7.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL342742 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL141319 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL141485 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL358268 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL142456 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL143447 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL142211 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL141494 | — | IC50 | = | 25.0 | nM | 7.60 |