Assay Detail
Binding
CHEMBL670364
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Inhibition of mouse Dopamine receptor D2
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and evaluation of heterocyclic carboxamides as potential antipsychotic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.75 | 8.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL343838 | — | — | 1 | 8.66 |
| CHEMBL142850 | — | — | 1 | 8.24 |
| CHEMBL143075 | — | — | 1 | 8.22 |
| CHEMBL141392 | — | — | 1 | 8.11 |
| CHEMBL141438 | — | — | 1 | 8.02 |
| CHEMBL85 | RISPERIDONE | 4.0 | 1 | 7.64 |
| CHEMBL344994 | — | — | 1 | 7.62 |
| CHEMBL356743 | — | — | 1 | 7.55 |
| CHEMBL343228 | — | — | 1 | 7.55 |
| CHEMBL142277 | — | — | 1 | 7.47 |
| CHEMBL356498 | — | — | 1 | 7.33 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 6.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL343838 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL142850 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL143075 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL141392 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL141438 | — | IC50 | = | 9.6 | nM | 8.02 |
| CHEMBL85 | RISPERIDONE | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL344994 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL356743 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL343228 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL142277 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL356498 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL42 | CLOZAPINE | IC50 | = | 290.0 | nM | 6.54 |