Assay Detail
Binding
CHEMBL670366
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In vitro binding affinity towards dopamine receptor D2
120
Total Activities
120
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Novel piperidine sigma receptor ligands as potential antipsychotic drugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 120 | 5.93 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL136064 | — | — | 1 | 8.15 |
| CHEMBL136794 | — | — | 1 | 8.00 |
| CHEMBL139963 | — | — | 1 | 7.85 |
| CHEMBL136781 | — | — | 1 | 7.47 |
| CHEMBL134527 | — | — | 1 | 7.38 |
| CHEMBL136509 | — | — | 1 | 7.26 |
| CHEMBL337337 | — | — | 1 | 7.24 |
| CHEMBL540322 | — | — | 1 | 6.96 |
| CHEMBL540585 | — | — | 1 | 6.94 |
| CHEMBL136615 | — | — | 1 | 6.75 |
| CHEMBL136743 | — | — | 1 | 6.73 |
| CHEMBL138281 | — | — | 1 | 6.71 |
| CHEMBL545552 | — | — | 1 | 6.66 |
| CHEMBL544616 | — | — | 1 | 6.66 |
| CHEMBL542740 | — | — | 1 | 6.52 |
| CHEMBL555865 | — | — | 1 | 6.43 |
| CHEMBL335327 | — | — | 1 | 6.42 |
| CHEMBL423353 | — | — | 1 | 6.37 |
| CHEMBL539567 | — | — | 1 | 6.31 |
| CHEMBL422634 | — | — | 1 | 6.27 |
| CHEMBL136963 | — | — | 1 | 6.25 |
| CHEMBL136768 | — | — | 1 | 6.22 |
| CHEMBL136789 | — | — | 1 | 6.15 |
| CHEMBL545081 | — | — | 1 | 6.11 |
| CHEMBL545546 | — | — | 1 | 6.10 |
| CHEMBL136621 | — | — | 1 | 6.09 |
| CHEMBL545784 | — | — | 1 | 6.09 |
| CHEMBL337810 | — | — | 1 | 6.08 |
| CHEMBL539358 | — | — | 1 | 6.06 |
| CHEMBL136622 | — | — | 1 | 6.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL136064 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL136794 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL139963 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL136781 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL134527 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL136509 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL337337 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL540322 | — | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL540585 | — | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL136615 | — | IC50 | = | 179.0 | nM | 6.75 |
| CHEMBL136743 | — | IC50 | = | 185.0 | nM | 6.73 |
| CHEMBL138281 | — | IC50 | = | 195.0 | nM | 6.71 |
| CHEMBL545552 | — | IC50 | = | 219.0 | nM | 6.66 |
| CHEMBL544616 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL542740 | — | IC50 | = | 305.0 | nM | 6.52 |
| CHEMBL555865 | — | IC50 | = | 368.0 | nM | 6.43 |
| CHEMBL335327 | — | IC50 | = | 381.0 | nM | 6.42 |
| CHEMBL423353 | — | IC50 | = | 428.0 | nM | 6.37 |
| CHEMBL539567 | — | IC50 | = | 488.0 | nM | 6.31 |
| CHEMBL422634 | — | IC50 | = | 539.0 | nM | 6.27 |
| CHEMBL136963 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL136768 | — | IC50 | = | 608.0 | nM | 6.22 |
| CHEMBL136789 | — | IC50 | = | 715.0 | nM | 6.15 |
| CHEMBL545081 | — | IC50 | = | 773.0 | nM | 6.11 |
| CHEMBL545546 | — | IC50 | = | 789.0 | nM | 6.10 |
| CHEMBL545784 | — | IC50 | = | 818.0 | nM | 6.09 |
| CHEMBL136621 | — | IC50 | = | 806.0 | nM | 6.09 |
| CHEMBL337810 | — | IC50 | = | 839.0 | nM | 6.08 |
| CHEMBL539358 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL136622 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL137085 | — | IC50 | = | 945.0 | nM | 6.03 |
| CHEMBL545781 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL424281 | — | IC50 | = | 1022.0 | nM | 5.99 |
| CHEMBL136835 | — | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL334466 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL555093 | — | IC50 | = | 1321.0 | nM | 5.88 |
| CHEMBL344240 | — | IC50 | = | 1345.0 | nM | 5.87 |
| CHEMBL343802 | — | IC50 | = | 1340.0 | nM | 5.87 |
| CHEMBL342267 | — | IC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL555975 | — | IC50 | = | 1573.0 | nM | 5.80 |
| CHEMBL543412 | — | IC50 | = | 1630.0 | nM | 5.79 |
| CHEMBL543439 | — | IC50 | = | 1652.0 | nM | 5.78 |
| CHEMBL136701 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL544372 | — | IC50 | = | 1718.0 | nM | 5.76 |
| CHEMBL543910 | — | IC50 | = | 1802.0 | nM | 5.74 |
| CHEMBL137658 | — | IC50 | = | 1850.0 | nM | 5.73 |
| CHEMBL543440 | — | IC50 | = | 1850.0 | nM | 5.73 |
| CHEMBL137768 | — | IC50 | = | 1930.0 | nM | 5.71 |
| CHEMBL544614 | — | IC50 | = | 2004.0 | nM | 5.70 |
| CHEMBL545549 | — | IC50 | = | 1979.0 | nM | 5.70 |