Assay Detail
Binding
CHEMBL670394
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In vitro binding affinity against human D2 dopamine receptor in CHO cells by [3H]spiperone displacement.
19
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis, SAR and pharmacology of CP-293,019: a potent, selective dopamine D4 receptor antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 6.66 | 9.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 9.08 |
| CHEMBL165504 | — | — | 2 | 7.42 |
| CHEMBL351611 | — | — | 1 | 7.36 |
| CHEMBL163009 | — | — | 1 | 7.17 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 6.81 |
| CHEMBL162265 | — | — | 1 | 6.73 |
| CHEMBL350160 | — | — | 1 | 6.73 |
| CHEMBL162873 | — | — | 1 | 6.71 |
| CHEMBL166321 | — | — | 1 | 6.69 |
| CHEMBL165113 | — | — | 1 | 6.59 |
| CHEMBL351098 | — | — | 1 | 6.04 |
| CHEMBL161899 | — | — | 1 | 6.02 |
| CHEMBL349699 | — | — | 1 | 6.01 |
| CHEMBL166269 | — | — | 1 | 5.94 |
| CHEMBL159903 | — | — | 1 | 5.92 |
| CHEMBL349904 | — | — | 1 | 5.76 |
| CHEMBL161982 | — | — | 1 | 5.73 |
| CHEMBL66227 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | Ki | = | 0.84 | nM | 9.08 |
| CHEMBL165504 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL351611 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL165504 | — | Ki | = | 66.0 | nM | 7.18 |
| CHEMBL163009 | — | Ki | = | 68.0 | nM | 7.17 |
| CHEMBL42 | CLOZAPINE | Ki | = | 155.0 | nM | 6.81 |
| CHEMBL350160 | — | Ki | = | 187.0 | nM | 6.73 |
| CHEMBL162265 | — | Ki | = | 185.0 | nM | 6.73 |
| CHEMBL162873 | — | Ki | = | 195.0 | nM | 6.71 |
| CHEMBL166321 | — | Ki | = | 206.0 | nM | 6.69 |
| CHEMBL165113 | — | Ki | = | 254.0 | nM | 6.59 |
| CHEMBL351098 | — | Ki | = | 918.0 | nM | 6.04 |
| CHEMBL161899 | — | Ki | = | 948.0 | nM | 6.02 |
| CHEMBL349699 | — | Ki | = | 980.0 | nM | 6.01 |
| CHEMBL166269 | — | Ki | = | 1140.0 | nM | 5.94 |
| CHEMBL159903 | — | Ki | = | 1196.0 | nM | 5.92 |
| CHEMBL349904 | — | Ki | = | 1720.0 | nM | 5.76 |
| CHEMBL161982 | — | Ki | = | 1880.0 | nM | 5.73 |
| CHEMBL66227 | — | Ki | > | 3310.0 | nM | - |