Assay Detail
Functional
CHEMBL670420
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Stimulation of mitogenesis in Dopamine receptor D3 transfected CHO p-5 cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
4-bromo-1-methoxy-N-[2-(4-aryl-1-piperazinyl)ethyl]-2-naphthalenecarboxamides: Selective dopamine D3 receptor partial agonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 7.42 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL287198 | — | — | 1 | 7.89 |
| CHEMBL442535 | — | — | 1 | 7.55 |
| CHEMBL29182 | — | — | 1 | 7.17 |
| CHEMBL30206 | — | — | 1 | 7.08 |
| CHEMBL28964 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL287198 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL442535 | — | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL29182 | — | EC50 | = | 68.0 | nM | 7.17 |
| CHEMBL30206 | — | EC50 | = | 83.0 | nM | 7.08 |
| CHEMBL28964 | — | EC50 | > | 1000.0 | nM | - |