Assay Detail
Binding
CHEMBL670536
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Binding affinity was evaluated by calculating competition for [3H]spiperone binding on Dopamine receptor D2L of CHO K-1 cells.
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Affinity for dopamine D2, D3, and D4 receptors of 2-aminotetralins. Relevance of D2 agonist binding for determination of receptor subtype selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 33 | 6.46 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL269004 | — | — | 1 | 8.22 |
| CHEMBL109684 | — | — | 1 | 7.72 |
| CHEMBL1303 | ROTIGOTINE | 4.0 | 1 | 7.70 |
| CHEMBL7806 | — | — | 1 | 7.62 |
| CHEMBL135932 | — | — | 1 | 7.26 |
| CHEMBL301559 | — | — | 1 | 7.25 |
| CHEMBL135954 | — | — | 1 | 7.23 |
| CHEMBL133830 | — | — | 1 | 7.11 |
| CHEMBL15146 | — | — | 1 | 7.05 |
| CHEMBL134701 | — | — | 1 | 6.92 |
| CHEMBL135048 | — | — | 1 | 6.88 |
| CHEMBL134571 | — | — | 1 | 6.76 |
| CHEMBL134759 | — | — | 1 | 6.75 |
| CHEMBL134866 | — | — | 1 | 6.74 |
| CHEMBL335392 | — | — | 1 | 6.72 |
| CHEMBL334472 | — | — | 1 | 6.54 |
| CHEMBL30560 | — | — | 1 | 6.48 |
| CHEMBL135152 | — | — | 1 | 6.42 |
| CHEMBL11615 | — | — | 1 | 6.38 |
| CHEMBL134747 | — | — | 1 | 6.28 |
| CHEMBL336295 | — | — | 1 | 6.26 |
| CHEMBL131851 | — | — | 1 | 6.16 |
| CHEMBL336652 | — | — | 1 | 6.08 |
| CHEMBL132261 | — | — | 1 | 5.98 |
| CHEMBL94015 | — | — | 1 | 5.93 |
| CHEMBL133938 | — | — | 1 | 5.91 |
| CHEMBL441092 | — | — | 1 | 5.83 |
| CHEMBL336962 | — | — | 1 | 5.49 |
| CHEMBL135944 | — | — | 1 | 5.47 |
| CHEMBL305706 | — | — | 1 | 5.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL269004 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL109684 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL1303 | ROTIGOTINE | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL7806 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL135932 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL301559 | — | Ki | = | 56.0 | nM | 7.25 |
| CHEMBL135954 | — | Ki | = | 59.0 | nM | 7.23 |
| CHEMBL133830 | — | Ki | = | 78.0 | nM | 7.11 |
| CHEMBL15146 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL134701 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL135048 | — | Ki | = | 131.0 | nM | 6.88 |
| CHEMBL134571 | — | Ki | = | 173.0 | nM | 6.76 |
| CHEMBL134759 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL134866 | — | Ki | = | 181.0 | nM | 6.74 |
| CHEMBL335392 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL334472 | — | Ki | = | 285.0 | nM | 6.54 |
| CHEMBL30560 | — | Ki | = | 334.0 | nM | 6.48 |
| CHEMBL135152 | — | Ki | = | 380.0 | nM | 6.42 |
| CHEMBL11615 | — | Ki | = | 416.0 | nM | 6.38 |
| CHEMBL134747 | — | Ki | = | 524.0 | nM | 6.28 |
| CHEMBL336295 | — | Ki | = | 550.0 | nM | 6.26 |
| CHEMBL131851 | — | Ki | = | 694.0 | nM | 6.16 |
| CHEMBL336652 | — | Ki | = | 836.0 | nM | 6.08 |
| CHEMBL132261 | — | Ki | = | 1046.0 | nM | 5.98 |
| CHEMBL94015 | — | Ki | = | 1183.0 | nM | 5.93 |
| CHEMBL133938 | — | Ki | = | 1241.0 | nM | 5.91 |
| CHEMBL441092 | — | Ki | = | 1492.0 | nM | 5.83 |
| CHEMBL336962 | — | Ki | = | 3206.0 | nM | 5.49 |
| CHEMBL135944 | — | Ki | = | 3351.0 | nM | 5.47 |
| CHEMBL305706 | — | Ki | = | 4777.0 | nM | 5.32 |
| CHEMBL422274 | — | Ki | = | 5825.0 | nM | 5.24 |
| CHEMBL134326 | — | Ki | = | 5882.0 | nM | 5.23 |
| CHEMBL335971 | — | Ki | = | 58882.0 | nM | 4.23 |