Assay Detail
Binding
CHEMBL670577
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Binding affinity towards human Dopamine receptor D3
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
New (sulfonyloxy)piperazinyldibenzazepines as potential atypical antipsychotics: chemistry and pharmacological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.29 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL73589 | — | — | 1 | 8.10 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 8.00 |
| CHEMBL831 | LOXAPINE | 4.0 | 1 | 7.66 |
| CHEMBL430798 | — | — | 1 | 7.54 |
| CHEMBL72292 | — | — | 1 | 7.28 |
| CHEMBL70319 | — | — | 1 | 7.28 |
| CHEMBL415300 | ISOCLOZAPINE | — | 1 | 6.92 |
| CHEMBL306474 | — | — | 1 | 6.46 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 6.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL73589 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL54 | HALOPERIDOL | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL831 | LOXAPINE | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL430798 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL72292 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL70319 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL415300 | ISOCLOZAPINE | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL306474 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL42 | CLOZAPINE | IC50 | = | 450.0 | nM | 6.35 |