Assay Detail
Binding
CHEMBL670634
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Affinity for human endothelin B receptor expressed in CHO-K1 cells.
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO-K1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
1-benzyl-3-thioaryl-2-carboxyindoles as potent non-peptide endothelin antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.92 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL28563 | — | — | 1 | 6.77 |
| CHEMBL28920 | — | — | 1 | 6.64 |
| CHEMBL27732 | — | — | 1 | 6.55 |
| CHEMBL287169 | — | — | 1 | 6.42 |
| CHEMBL283598 | — | — | 1 | 6.38 |
| CHEMBL283858 | — | — | 1 | 6.38 |
| CHEMBL29147 | — | — | 1 | 6.31 |
| CHEMBL281451 | — | — | 1 | 6.16 |
| CHEMBL27617 | — | — | 1 | 6.12 |
| CHEMBL28188 | — | — | 1 | 6.06 |
| CHEMBL285368 | — | — | 1 | 5.96 |
| CHEMBL416570 | — | — | 1 | 5.96 |
| CHEMBL285380 | — | — | 1 | 5.80 |
| CHEMBL28779 | — | — | 1 | 5.35 |
| CHEMBL282398 | — | — | 1 | 5.17 |
| CHEMBL283648 | — | — | 1 | 5.13 |
| CHEMBL28948 | — | — | 1 | 4.82 |
| CHEMBL282426 | — | — | 1 | 4.54 |
| CHEMBL27911 | — | — | 1 | - |
| CHEMBL435568 | — | — | 1 | - |
| CHEMBL10143 | — | — | 1 | - |
| CHEMBL416019 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL28563 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL28920 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL27732 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL287169 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL283598 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL283858 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL29147 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL281451 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL27617 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL28188 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL285368 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL416570 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL285380 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL28779 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL282398 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL283648 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL28948 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL282426 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL27911 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL435568 | — | IC50 | > | 2500.0 | nM | - |
| CHEMBL10143 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL416019 | — | IC50 | > | 25000.0 | nM | - |