Assay Detail
Binding
CHEMBL670642
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro for specific binding of [125I]ET1 to GHcell expressed in Endothelin B receptor
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Potent and selective ET-A antagonists. 1. Syntheses and structure-activity relationships of N-(6-(2-(aryloxy)ethoxy)-4-pyrimidinyl)sulfonamide derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.47 | 8.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL367445 | — | — | 1 | 8.42 |
| CHEMBL175501 | — | — | 1 | 8.15 |
| CHEMBL176272 | — | — | 1 | 7.55 |
| CHEMBL369489 | — | — | 1 | 7.42 |
| CHEMBL177979 | — | — | 1 | 6.66 |
| CHEMBL368796 | — | — | 1 | 6.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL367445 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL175501 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL176272 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL369489 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL177979 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL368796 | — | IC50 | = | 240.0 | nM | 6.62 |