Assay Detail
Binding
CHEMBL670667
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]U-86170 from human D2-dopamine receptor expressed in CHO K1 cells
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Novel 2-substituted tetrahydro-3H-benz[e]indolamines: highly potent and selective agonists acting at the 5-HT1A receptor as possible anxiolytics and antidepressants.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 6.84 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL49 | BUSPIRONE | 4.0 | 1 | 7.89 |
| CHEMBL71920 | U-92,016-A | — | 1 | 7.46 |
| CHEMBL1744037 | — | — | 1 | 7.42 |
| CHEMBL1744088 | — | — | 1 | 7.36 |
| CHEMBL26998 | — | — | 1 | 7.03 |
| CHEMBL1744036 | — | — | 1 | 6.67 |
| CHEMBL1788192 | — | — | 1 | 6.41 |
| CHEMBL1744089 | — | — | 1 | 6.07 |
| CHEMBL1744035 | — | — | 1 | 6.05 |
| CHEMBL1788191 | — | — | 1 | 6.04 |
| CHEMBL1744038 | — | — | 1 | - |
| CHEMBL1788325 | — | — | 1 | - |
| CHEMBL1788190 | — | — | 1 | - |
| CHEMBL1788324 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL49 | BUSPIRONE | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL71920 | U-92,016-A | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL1744037 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL1744088 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL26998 | — | Ki | = | 93.0 | nM | 7.03 |
| CHEMBL1744036 | — | Ki | = | 215.0 | nM | 6.67 |
| CHEMBL1788192 | — | Ki | = | 389.0 | nM | 6.41 |
| CHEMBL1744089 | — | Ki | = | 857.0 | nM | 6.07 |
| CHEMBL1744035 | — | Ki | = | 896.0 | nM | 6.05 |
| CHEMBL1788191 | — | Ki | = | 914.0 | nM | 6.04 |
| CHEMBL1744038 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL1788325 | — | Ki | > | 1667.0 | nM | - |
| CHEMBL1788190 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL1788324 | — | Ki | > | 333.0 | nM | - |