Assay Detail
Binding
CHEMBL670681
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Binding affinity towards dopamine receptor D2
26
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Chemoenzymatic synthesis and binding affinity of novel (R)- and (S)-3-aminomethyl-1-tetralones, potential atypical antipsychotics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 26 | 6.71 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 9.22 |
| CHEMBL155486 | — | — | 3 | 7.24 |
| CHEMBL308480 | — | — | 3 | 6.98 |
| CHEMBL155257 | — | — | 3 | 6.97 |
| CHEMBL153956 | — | — | 3 | 6.71 |
| CHEMBL310153 | — | — | 1 | 6.69 |
| CHEMBL155426 | — | — | 1 | 6.65 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 6.65 |
| CHEMBL155388 | — | — | 3 | 6.56 |
| CHEMBL155124 | — | — | 1 | 6.40 |
| CHEMBL421801 | — | — | 3 | 6.36 |
| CHEMBL157046 | — | — | 1 | 6.08 |
| CHEMBL348617 | — | — | 1 | - |
| CHEMBL154244 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | Ki | = | 0.6026 | nM | 9.22 |
| CHEMBL155486 | — | Ki | = | 57.54 | nM | 7.24 |
| CHEMBL155486 | — | Ki | = | 64.57 | nM | 7.19 |
| CHEMBL308480 | — | Ki | = | 104.71 | nM | 6.98 |
| CHEMBL155257 | — | Ki | = | 107.15 | nM | 6.97 |
| CHEMBL155257 | — | Ki | = | 151.36 | nM | 6.82 |
| CHEMBL155257 | — | Ki | = | 162.18 | nM | 6.79 |
| CHEMBL153956 | — | Ki | = | 194.98 | nM | 6.71 |
| CHEMBL310153 | — | Ki | = | 204.17 | nM | 6.69 |
| CHEMBL155486 | — | Ki | = | 213.8 | nM | 6.67 |
| CHEMBL308480 | — | Ki | = | 223.87 | nM | 6.65 |
| CHEMBL42 | CLOZAPINE | Ki | = | 223.87 | nM | 6.65 |
| CHEMBL155426 | — | Ki | = | 223.87 | nM | 6.65 |
| CHEMBL155388 | — | Ki | = | 275.42 | nM | 6.56 |
| CHEMBL155388 | — | Ki | = | 316.23 | nM | 6.50 |
| CHEMBL308480 | — | Ki | = | 338.84 | nM | 6.47 |
| CHEMBL153956 | — | Ki | = | 380.19 | nM | 6.42 |
| CHEMBL155124 | — | Ki | = | 398.11 | nM | 6.40 |
| CHEMBL421801 | — | Ki | = | 436.52 | nM | 6.36 |
| CHEMBL421801 | — | Ki | = | 457.09 | nM | 6.34 |
| CHEMBL421801 | — | Ki | = | 501.19 | nM | 6.30 |
| CHEMBL153956 | — | Ki | = | 537.03 | nM | 6.27 |
| CHEMBL157046 | — | Ki | = | 831.76 | nM | 6.08 |
| CHEMBL155388 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL348617 | — | Ki | < | 10000.0 | nM | - |
| CHEMBL154244 | — | Ki | < | 10000.0 | nM | - |