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Assay Detail

CHEMBL670682

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding potency of compound for Dopamine receptor D2 by displacement of [3H]spiperone
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

D(2) dopamine receptor (CHEMBL217)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Conformational analysis and molecular modeling of 1-phenyl-, 4-phenyl-, and 1-benzyl-1,2,3,4-tetrahydroisoquinolines as D1 dopamine receptor ligands.
Charifson PS, Bowen JP, Wyrick SD, Hoffman AJ, Cory M, McPhail AT, Mailman RB.
J Med Chem (1989) 32 : 2050 -2058
PubMed 2527994 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 5.74 5.74

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL59603 1 5.74

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL59603 Ki = 1819.7 nM 5.74