Assay Detail
Binding
CHEMBL670683
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Binding potency of compound for Dopamine receptor D2 by displacement of [3H]spiperone
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Conformational analysis and molecular modeling of 1-phenyl-, 4-phenyl-, and 1-benzyl-1,2,3,4-tetrahydroisoquinolines as D1 dopamine receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 5.87 | 6.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL64117 | — | — | 1 | 6.84 |
| CHEMBL302393 | — | — | 1 | 6.58 |
| CHEMBL62 | SCH-23390 | — | 1 | 6.05 |
| CHEMBL303993 | — | — | 1 | 5.73 |
| CHEMBL293828 | — | — | 1 | 5.72 |
| CHEMBL65397 | — | — | 1 | 5.43 |
| CHEMBL293158 | — | — | 1 | 4.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL64117 | — | Ki | = | 144.54 | nM | 6.84 |
| CHEMBL302393 | — | Ki | = | 263.03 | nM | 6.58 |
| CHEMBL62 | SCH-23390 | Ki | = | 891.25 | nM | 6.05 |
| CHEMBL303993 | — | Ki | = | 1862.09 | nM | 5.73 |
| CHEMBL293828 | — | Ki | = | 1905.46 | nM | 5.72 |
| CHEMBL65397 | — | Ki | = | 3715.35 | nM | 5.43 |
| CHEMBL293158 | — | Ki | = | 19054.61 | nM | 4.72 |