Assay Detail
Binding
CHEMBL670689
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Binding affinity was evaluated by calculating competition for [3H]spiperone binding on Dopamine receptor D4.2 of CHO K-1 cells.
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Affinity for dopamine D2, D3, and D4 receptors of 2-aminotetralins. Relevance of D2 agonist binding for determination of receptor subtype selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 33 | 6.64 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL135954 | — | — | 1 | 7.66 |
| CHEMBL336295 | — | — | 1 | 7.64 |
| CHEMBL335392 | — | — | 1 | 7.50 |
| CHEMBL269004 | — | — | 1 | 7.33 |
| CHEMBL134747 | — | — | 1 | 7.27 |
| CHEMBL109684 | — | — | 1 | 7.27 |
| CHEMBL1303 | ROTIGOTINE | 4.0 | 1 | 7.26 |
| CHEMBL7806 | — | — | 1 | 7.14 |
| CHEMBL334472 | — | — | 1 | 7.12 |
| CHEMBL301559 | — | — | 1 | 6.96 |
| CHEMBL133938 | — | — | 1 | 6.87 |
| CHEMBL15146 | — | — | 1 | 6.74 |
| CHEMBL336652 | — | — | 1 | 6.57 |
| CHEMBL132261 | — | — | 1 | 6.49 |
| CHEMBL135944 | — | — | 1 | 6.47 |
| CHEMBL135152 | — | — | 1 | 6.31 |
| CHEMBL135048 | — | — | 1 | 6.22 |
| CHEMBL11615 | — | — | 1 | 6.20 |
| CHEMBL135932 | — | — | 1 | 6.14 |
| CHEMBL134866 | — | — | 1 | 6.13 |
| CHEMBL134701 | — | — | 1 | 6.02 |
| CHEMBL134571 | — | — | 1 | 5.99 |
| CHEMBL134326 | — | — | 1 | 5.82 |
| CHEMBL134759 | — | — | 1 | 5.82 |
| CHEMBL94015 | — | — | 1 | 5.16 |
| CHEMBL30560 | — | — | 1 | - |
| CHEMBL335971 | — | — | 1 | - |
| CHEMBL336962 | — | — | 1 | - |
| CHEMBL422274 | — | — | 1 | - |
| CHEMBL305706 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL135954 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL336295 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL335392 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL269004 | — | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL134747 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL109684 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL1303 | ROTIGOTINE | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL7806 | — | Ki | = | 72.0 | nM | 7.14 |
| CHEMBL334472 | — | Ki | = | 76.0 | nM | 7.12 |
| CHEMBL301559 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL133938 | — | Ki | = | 134.0 | nM | 6.87 |
| CHEMBL15146 | — | Ki | = | 182.0 | nM | 6.74 |
| CHEMBL336652 | — | Ki | = | 269.0 | nM | 6.57 |
| CHEMBL132261 | — | Ki | = | 324.0 | nM | 6.49 |
| CHEMBL135944 | — | Ki | = | 335.0 | nM | 6.47 |
| CHEMBL135152 | — | Ki | = | 485.0 | nM | 6.31 |
| CHEMBL135048 | — | Ki | = | 603.0 | nM | 6.22 |
| CHEMBL11615 | — | Ki | = | 634.0 | nM | 6.20 |
| CHEMBL135932 | — | Ki | = | 729.0 | nM | 6.14 |
| CHEMBL134866 | — | Ki | = | 734.0 | nM | 6.13 |
| CHEMBL134701 | — | Ki | = | 964.0 | nM | 6.02 |
| CHEMBL134571 | — | Ki | = | 1033.0 | nM | 5.99 |
| CHEMBL134326 | — | Ki | = | 1504.0 | nM | 5.82 |
| CHEMBL134759 | — | Ki | = | 1519.0 | nM | 5.82 |
| CHEMBL94015 | — | Ki | = | 7000.0 | nM | 5.16 |
| CHEMBL30560 | — | Ki | > | 33333.0 | nM | - |
| CHEMBL335971 | — | Ki | > | 3333.0 | nM | - |
| CHEMBL336962 | — | Ki | > | 3333.0 | nM | - |
| CHEMBL422274 | — | Ki | > | 3333.0 | nM | - |
| CHEMBL305706 | — | Ki | > | 3333.0 | nM | - |
| CHEMBL133830 | — | Ki | > | 3333.0 | nM | - |
| CHEMBL441092 | — | Ki | > | 3333.0 | nM | - |
| CHEMBL131851 | — | Ki | > | 3333.0 | nM | - |