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Assay Detail

CHEMBL670743

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Compound was evaluated for the binding affinity towards Dopamine receptor D2 from mammalian clones expressed in CHO cell membranes using 2 (86.1 Ci/mmol,1.7nanoM)as radioligand
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Cell Type CHO
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

D(2) dopamine receptor (CHEMBL217)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Novel indolodioxanes with antihypertensive effects: potent ligands for the 5-HT1A receptor.
Ennis MD, Baze ME, Smith MW, Lawson CF, McCall RB, Lahti RA, Piercey MF.
J Med Chem (1992) 35 : 3058 -3066
PubMed 1323682 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 9.70 9.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL317433 1 9.70

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL317433 Ki = 0.2 nM 9.70