Assay Detail
Binding
CHEMBL670790
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to dopamine transporter in membranes of cells selectively expressing the human genes for DAT
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent dopamine transporter (CHEMBL238) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and monoamine transporter affinity of 3'-analogs of 2-beta-carbomethoxy-3-beta-(4'-iodophenyl)tropane (beta-CIT).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.55 | 9.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL311347 | — | — | 1 | 9.32 |
| CHEMBL294733 | — | — | 1 | 8.05 |
| CHEMBL303232 | — | — | 1 | 7.53 |
| CHEMBL303494 | — | — | 1 | 7.27 |
| CHEMBL67387 | — | — | 1 | 6.74 |
| CHEMBL66068 | — | — | 1 | 6.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL311347 | — | Ki | = | 0.48 | nM | 9.32 |
| CHEMBL294733 | — | Ki | = | 8.83 | nM | 8.05 |
| CHEMBL303232 | — | Ki | = | 29.8 | nM | 7.53 |
| CHEMBL303494 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL67387 | — | Ki | = | 182.0 | nM | 6.74 |
| CHEMBL66068 | — | Ki | = | 438.0 | nM | 6.36 |