Assay Detail
Binding
CHEMBL670825
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Affinity was evaluated using [3H]WIN-35428 (radioligand) on Cloned human Dopamine transporter expressed in HEK cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HEK293 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent dopamine transporter (CHEMBL238) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Tolerance in the replacement of the benzhydrylic O atom in 4-[2-(diphenylmethoxy)ethyl]-1-benzylpiperidine derivatives by an N atom: development of new-generation potent and selective N-analogue molecules for the dopamine transporter.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.12 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL110530 | — | — | 1 | 7.52 |
| CHEMBL444592 | — | — | 1 | 7.48 |
| CHEMBL34032 | — | — | 1 | 7.46 |
| CHEMBL20648 | — | — | 1 | 7.42 |
| CHEMBL281594 | VANOXERINE | 3.0 | 1 | 7.37 |
| CHEMBL109776 | — | — | 1 | 5.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL110530 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL444592 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL34032 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL20648 | — | IC50 | = | 37.6 | nM | 7.42 |
| CHEMBL281594 | VANOXERINE | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL109776 | — | IC50 | = | 3213.0 | nM | 5.49 |